PRP THERAPY – Autologous Conditioned Plasma (ACP)

event 28.08.2017.

Wound healing is a complex process involving many biological mechanisms. Platelets play a key role in hemostasis and tissue healing, i.e. their ability to release bioactive substances such as growth factors, cytokines, and chemokines during the activation phase.

Thrombocytes or platelets are small colorless bodies in the blood that we know for their role in clotting. When they are not active, they travel in the bloodstream. When an injury occurs, they are activated, gather at the site of the injury, branch out over the injured tissue and thus begin the healing process. The fact that in their active phase they secrete active metabolites means that they accelerate healing, i.e. they influence tissue repair, the reactivity of blood vessels and other blood cells in angiogenesis and inflammation.

Platelet-rich plasma (ACP autologous conditioned plasma or PRP platelet-rich plasma) is a volume of autologous plasma in which the concentration of platelets is above the normal level. Plasma is the liquid part of the blood that contains proteins, some lipids, and most of it is water.

An increased level of platelets, i.e. bioactive substances in the plasma volume, leads to the activation of intercellular processes with increased production of proteins necessary for regenerative processes, such as:

  • epithelialization – a process during which cells multiply to cover the damage again
  • contraction – spontaneous closure of full-thickness wounds
  • extracellular matrix deposition – connective cells (fibroblasts) at the site of injury produce new connective tissue.

ACP preparation

Using a special needle, a sample of venous blood is extracted, which is then separated using a special centrifugation system. In this way, three completely separated parts of blood are obtained. At the bottom is a layer of erythrocytes, in the middle of platelets, and at the top is plasma. The thus obtained serum (plasma and erythrocytes) is applied to the site of pain. The whole procedure takes about 20 minutes. Depending on the indication, it is applied 3 to 5 times, at intervals of 7 days.

ACP is an autologous therapy, which means that there are no negative reactions because the preparation is obtained from one’s own blood. This type of therapy is contraindicated only during pregnancy and breastfeeding and in people who are allergic to Bupivacaine (Marcaine). It can also be used in patients suffering from diabetes, unlike previous infiltrations with corticosteroid drugs that can raise blood sugar levels.

Soft tissues, such as tendons and ligaments heal with a scar. This negatively affects the function of the joint and increases the possibility of re-injury. Therefore, we apply ACP in the healing of bone tissue, tendon structures, and ligaments, and wherever there is a need for more extensive revascularization, greater collagen formation, and better mechanical characteristics, i.e. in the treatment of:

  • EPICONDYLITIS
  • ACHILLES TENDON RUPTURES
  • RUPTURES OF THE ROTATOR CUFF
  • MUSCLE RUPTURE
  • ACCELERATED POSTOPERATIVE HEALING
  • CHRONIC INFLAMMATORY CONDITIONS OF THE TENDON APPARATUS
  • HEEL THICKNESS AND INFLAMMATION OF THE FASCIA OF THE FOOT.